Contrast-Induced Nephropathy other intervention, for example, percutaneous coronary intervention. All of the patients received low-osmolar or iso-osmolar contrast media and median contrast volume Nigericin (sodium salt) biological activity ranged from 93 ml to 240 ml. Periprocedural hydration was used in every one, except the patients without pre-existing renal failure in the study by Patti G et al. Five studies used atorvastatin and simvastatin was used in the other two studies. The duration of statin treatment ranged from 3 to.7 days and the total dose ranged from 140 mg to.460 mg in the high-dose statin treatment group. Two of the included studies also used 7 Statin Prevents Contrast-Induced Nephropathy oral N-acetylcysteine twice daily in both arms, started the day before the procedure. Allocation concealment and blinding were used in three studies and the quality characteristics of the studies were shown in table 3. Effects of statin treatment on clinical outcomes The overall results based on fixed-effect model showed that the use of short-term high-dose statin treatment was associated with a significant reduction in risk of CIN. The incidence of acute renal failure requiring dialysis was very low and was not significant different after the use of statin. In-hospital mortality was observed in only one patient who died from acute heart failure aggravated by major bleeding in these seven studies. Although the study carried out by Zhou Xia et al reported incidence of cardiovascular event 
in short-term high-dose treatment group and low-dose group, it didn’t give any details. The total length of hospital stay were reported only in two studies. There was no difference between statin-treated group “8201586
“and control group in length of hospital stay in the study by Jo SH et al. However, length of stay after intervention was shorter in patients randomized to atorvastatin in the other study. Subgroup analysis Classified according to low-dose statin-treated or not in control group, studies comparing short-term high-dose statin treatment with non-statin treatment showed a significant protective trend toward decreased incidence of CIN and the same effect was seen in other two studies which compared short-term high-dose with low-dose statin treament. In all five studies in which statin was compared with control without the addition of NAC, the risk of CIN was significantly decreased. In contrast, the risk of CIN did not significantly differ in the two studies in which statin plus NAC versus NAC only. In studies that included patients without renal impairment at baseline, RR was 0.29. A reduced ” risk of CIN was not found in studies that included patients with pre-existing renal impairment. RR for CIN associated with the use ” of statin was 0.79. Classified according to the Jadad score.3 or not, studies whose Jadad score3 showed a significant reduction of CIN. However, the risk of CIN did not significantly differ in the studies whose Jadad score.3. Discussion In the past two decades, although hydration has been well recognized and widely performed to prevent the CIN, the incidence of CIN did not decrease. So the efficacy of many other interventions are still under testing. From 2004 to 2011, a few studies focused on using statin as a specific prophylactic measure of CIN prevention have been published. In this meta-analysis of 7 randomized controlled trials, we found that statin could significantly reduce the risk of CIN without decreasing the incidence of death or need for dialysis. However, there wa
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