, Wei H, Gao X, Chen Y, et al. Accelerated 25331948 liver inhibitor fibrosis in hepatitis B virus transgenic mice: involvement of organic killer T cells. Hepatology 53: 219229. 21. Jochum W, Passegue E, Wagner EF AP-1 in mouse improvement and tumorigenesis. Oncogene 20: 24012412. 22. He G, Karin M NF-kappaB and ST. Cell Res 21: 159168. 23. Eferl R, Ricci R, Kenner L, Zenz R, David JP, et al. Liver tumor improvement. c-Jun antagonizes the proapoptotic activity of p53. Cell 112: 181 192. 24. He G, Yu GY, Temkin V, Ogata H, Kuntzen C, et al. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by stopping oxidative stress-driven STAT3 activation. Cancer Cell 17: 286297. 25. Salguero PR, Roderfeld M, Hemmann S, Rath T, Atanasova S, et al. Activation of hepatic stellate cells is connected with cytokine expression in thioacetamide-induced hepatic fibrosis in mice. Lab Invest 88: 11921203. 26. Boigk G, Stroedter L, Herbst H, Waldschmidt J, Riecken EO, et al. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to finish bile duct obliteration in rats. Hepatology 26: 643649. 27. Glebe D, Aliakbari M, Krass P, Knoop EV, Valerius KP, et al. Pre-s1 antigen-dependent infection of Tupaia hepatocyte cultures with human hepatitis B virus. J Virol 77: 95119521. 28. Sohlenius-Sternbeck AK Determination of the hepatocellularity quantity for human, dog, rabbit, rat and mouse livers from protein concentration measurements. Toxicol In Vitro 20: 15821586. 29. Roderfeld M, Rath T, Voswinckel R, Dierkes C, Dietrich H, et al. Bone marrow transplantation demonstrates medullar origin of CD34+ fibrocytes and ameliorates hepatic fibrosis in Abcb4-/- mice. Hepatology 51: 267276. 30. Pfaffl MW A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 29: e45. 31. Reece ST, Loddenkemper C, Askew DJ, Zedler U, Schommer-Leitner S, et al. Serine protease activity contributes to manage of Mycobacterium tuberculosis in hypoxic lung granulomas in mice. J Clin Invest 120: 33653376. 32. Wek RC, Jiang HY, Anthony TG Coping with pressure: eIF2 kinases and translational handle. Biochem Soc Trans 34: 711. 33. Lee UE, Friedman SL Mechanisms of hepatic fibrogenesis. Ideal Pract Res Clin Gastroenterol 25: 195206. 34. Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR Phosphorylation of c-jun mediated by MAP kinases. Nature 353: 670674. 35. Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354: 494496. 36. Pol S Management of HBV in immunocompromised individuals. Liver Int 33 Suppl 1: 182187. 37. Lau JY, Bain VG, Davies SE, Alexander GJ, Williams R Export of intracellular HBsAg in chronic hepatitis B virus infection is related to viral replication. Hepatology 14: 416421. 38. Naoumov NV, Portmann BC, Tedder RS, 25331948 Ferns B, Eddleston AL, et al. Detection of hepatitis B virus antigens in liver tissue. A relation to viral replication and histology in chronic hepatitis B infection. Gastroenterology 99: 12481253. 39. Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, et al. IRE1 signaling impacts cell fate through the Autophagy unfolded protein response. Science 318: 944949. 40. Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, et al. Activation and dysregulation on the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 134: 568576. 41. Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zha., Wei H, Gao X, Chen Y, et al. Accelerated 25331948 liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. Hepatology 53: 219229. 21. Jochum W, Passegue E, Wagner EF AP-1 in mouse development and tumorigenesis. Oncogene 20: 24012412. 22. He G, Karin M NF-kappaB and ST. Cell Res 21: 159168. 23. Eferl R, Ricci R, Kenner L, Zenz R, David JP, et al. Liver tumor improvement. c-Jun antagonizes the proapoptotic activity of p53. Cell 112: 181 192. 24. He G, Yu GY, Temkin V, Ogata H, Kuntzen C, et al. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell 17: 286297. 25. Salguero PR, Roderfeld M, Hemmann S, Rath T, Atanasova S, et al. Activation of hepatic stellate cells is connected with cytokine expression in thioacetamide-induced hepatic fibrosis in mice. Lab Invest 88: 11921203. 26. Boigk G, Stroedter L, Herbst H, Waldschmidt J, Riecken EO, et al. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to finish bile duct obliteration in rats. Hepatology 26: 643649. 27. Glebe D, Aliakbari M, Krass P, Knoop EV, Valerius KP, et al. Pre-s1 antigen-dependent infection of Tupaia hepatocyte cultures with human hepatitis B virus. J Virol 77: 95119521. 28. Sohlenius-Sternbeck AK Determination of the hepatocellularity quantity for human, dog, rabbit, rat and mouse livers from protein concentration measurements. Toxicol In Vitro 20: 15821586. 29. Roderfeld M, Rath T, Voswinckel R, Dierkes C, Dietrich H, et al. Bone marrow transplantation demonstrates medullar origin of CD34+ fibrocytes and ameliorates hepatic fibrosis in Abcb4-/- mice. Hepatology 51: 267276. 30. Pfaffl MW A brand new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 29: e45. 31. Reece ST, Loddenkemper C, Askew DJ, Zedler U, Schommer-Leitner S, et al. Serine protease activity contributes to manage of Mycobacterium tuberculosis in hypoxic lung granulomas in mice. J Clin Invest 120: 33653376. 32. Wek RC, Jiang HY, Anthony TG Coping with strain: eIF2 kinases and translational handle. Biochem Soc Trans 34: 711. 33. Lee UE, Friedman SL Mechanisms of hepatic fibrogenesis. Greatest Pract Res Clin Gastroenterol 25: 195206. 34. Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR Phosphorylation of c-jun mediated by MAP kinases. Nature 353: 670674. 35. Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M Oncogenic and transcriptional cooperation with Ha-Ras calls for phosphorylation of c-Jun on serines 63 and 73. Nature 354: 494496. 36. Pol S Management of HBV in immunocompromised patients. Liver Int 33 Suppl 1: 182187. 37. Lau JY, Bain VG, Davies SE, Alexander GJ, Williams R Export of intracellular HBsAg in chronic hepatitis B virus infection is associated to viral replication. Hepatology 14: 416421. 38. Naoumov NV, Portmann BC, Tedder RS, 25331948 Ferns B, Eddleston AL, et al. Detection of hepatitis B virus antigens in liver tissue. A relation to viral replication and histology in chronic hepatitis B infection. Gastroenterology 99: 12481253. 39. Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, et al. IRE1 signaling affects cell fate throughout the unfolded protein response. Science 318: 944949. 40. Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, et al. Activation and dysregulation on the unfolded protein response in nonalcoholic fatty liver illness. Gastroenterology 134: 568576. 41. Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zha.

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