Mouse MFAP5 Protein 3692

Additional Information:
inaccessionQ9QZJ6|express systemHEK293|product tagC-hFc|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundHuman basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibrillar-associated protein 5 (MFAP5) plays an important role in the integration of elastic microfibers and the regulation of endothelial cell behaviors.MFAP5 was significantly overexpressed in BLBC tissues and associated with poor metastasis-free survival of patients with BLBC.|molecular weightThe protein has a predicted MW of 42.4 kDa. Due to furin cleavage and glycosylation, the protein migrates to 32-38 kDa and 50-65 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse MFAP5 Protein 3692proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceHuman basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibrillar-associated protein 5 (MFAP5) plays an important role in the integration of elastic microfibers and the regulation of endothelial cell behaviors.MFAP5 was significantly overexpressed in BLBC tissues and associated with poor metastasis-free survival of patients with BLBC.Protein namesMicrofibrillar-associated protein 5 (MFAP-5) (Microfibril-associated glycoprotein 2) (MAGP-2)Gene namesMfap5,Mfap5 Magp2Protein familyMFAP familyMass10090DaFunctionMay play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (PubMed:23963447). Component of the elastin-associated microfibrils (By similarity).Subellular locationSecreted, extracellular space, extracellular matrix .StructureInteracts with TGFB2 (PubMed:23963447). Interacts with BMP2. Interacts with FBN1 (via N-terminal domain) and FBN2 (By similarity).Post-translational modificationForms intermolecular disulfide bonds either with other MAGP-2 molecules or with other components of the microfibrils.Target Relevance information above includes information from UniProt accession: Q9QZJ6The UniProt Consortium|