East cancer, pancreatic cancer Monotherapy in sufferers with deleterious or suspected deleterious germline Brca mutated (as detected by an FDa-approved test) sophisticated ovarian cancer that have been treated with 3 or more prior lines of chemotherapy ALL, GIST, dermatofibrosarcoma protuberans, CML, myelodysplastic syndrome, systemic mastocytosis advance renal cell carcinoma, some hepatocellular carcinoma Metastatic renal cell carcinoma, gisT (no response to imatinib), pancreatic neuroendocrine tumor advanced renal cell carcinoma, advanced soft tissue sarcoma cMl sophisticated renal cell carcinoma all, cMl A number of myeloma, mantle cell lymphoma Many myelomaado-trastuzumab emtansine (KaDcYla)afatinib (gilOTriF)Pertuzumab (PerJeTa)GSR HDAC1 HDAC2 KITglutathione reductase, mitochondrial histone deacetylase 1 histone deacetylase 2 Mast/stem cell development element receptor kitcarmustine (gliaDelWaFer) Vorinostat (Zolinza) romidepsin (istodax) imatinib mesylate (gleevec) sorafenib (nexavar) sunitinib (sutent) Pazopanib (Votrient) Dasatinib (sprycel) axitinib (inlyta) nilotinib (Tasigna) lenvatinib (lenvima) cabozantinib (cOMeTriQ) crizotinib (XalKOri)FGFR1 METFibroblast development factor receptor 1 hepatocyte development issue receptorMTORserine/threonine NS-018 (hydrochloride) protein kinase mTOr Poly (aDP-ribose) polymeraseTemsirolimus (Torisel) Everolimus (Afinitor) Olaparib (aZD2281)PARPPDGFRPlatelet-derived development aspect receptor alphaimatinib mesylate (gleevac) sorafenib (nexavar) sunitinib (sutent) Pazopanib (Votrient) nilotinib (Tasigna) axitinib (inlyta) Dasatinib (sprycel) Bortezomib (Velcade) Carfilzomib (Kyprolis)PSMC2 PSMC5 PSMC26s protease regulatory subunit 7 26s protease regulatory subunit eight 26s protease regulatory subunit 10BNote: ainformation from Termglinchan et al and DrugBank Version 4.5. republished with permission of Dovepress, from Onco Targets Ther, candidate cancer-targeting agents identified by expression-profiling arrays, Termglinchan V, Wanichnopparat W, Suwanwongse K, et al, six, copyright 2013; permission conveyed via Copyright Clearance center, inc.77 Wishart Ds, Knox c, guo ac, et al. DrugBank: a extensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006;34(Database concern):D668 672, by permission of Oxford University Press.78 Abbreviations: FDa, Meals and Drug administration; her2, human epidermal growth element receptor two; nsclc, non-small-cell lung cancer; egFr, epidermal development factor receptor; all, acute lymphoid leukemia; gisT, gastrointestinal stromal tumor; cMl, chronic myeloid leukemia; rcc, renal cell carcinoma; alK, anaplastic lymphoma kinase.OncoTargets and Therapy 2017:submit your manuscript | www.dovepress.comDovepresschaiyawat et alDovepressTable six Up-regulated proteins and genes which can be targets of FDa-approved SPDB biological activity non-antineoplastic drugsGene ATP1A1 ATP1B1 DHODH Protein name na+/K+-aTPase Dihydroorotate dehydrogenase (quinone), mitochondrial FDA-approved drug Digoxin Digitoxin Leflunomide Drug category antiarrhythmia agent immunosuppressive agent Illness indicationa For the treatment and management of congestive cardiac insufficiency, arrhythmias, and heart failure. For the management from the signs and symptoms of active ra. has also been utilized for the prevention of acute and chronic rejection in recipients of strong organ trasnplants and is designated by the FDa as an orphan drug for PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19927011 this use. For the prophylaxis of organ rejection in sufferers receiving allogeneic renal, cardiac, or hepatic transplants.East cancer, pancreatic cancer Monotherapy in individuals with deleterious or suspected deleterious germline Brca mutated (as detected by an FDa-approved test) sophisticated ovarian cancer who have been treated with three or much more prior lines of chemotherapy ALL, GIST, dermatofibrosarcoma protuberans, CML, myelodysplastic syndrome, systemic mastocytosis advance renal cell carcinoma, some hepatocellular carcinoma Metastatic renal cell carcinoma, gisT (no response to imatinib), pancreatic neuroendocrine tumor sophisticated renal cell carcinoma, advanced soft tissue sarcoma cMl sophisticated renal cell carcinoma all, cMl A number of myeloma, mantle cell lymphoma Numerous myelomaado-trastuzumab emtansine (KaDcYla)afatinib (gilOTriF)Pertuzumab (PerJeTa)GSR HDAC1 HDAC2 KITglutathione reductase, mitochondrial histone deacetylase 1 histone deacetylase 2 Mast/stem cell development factor receptor kitcarmustine (gliaDelWaFer) Vorinostat (Zolinza) romidepsin (istodax) imatinib mesylate (gleevec) sorafenib (nexavar) sunitinib (sutent) Pazopanib (Votrient) Dasatinib (sprycel) axitinib (inlyta) nilotinib (Tasigna) lenvatinib (lenvima) cabozantinib (cOMeTriQ) crizotinib (XalKOri)FGFR1 METFibroblast development factor receptor 1 hepatocyte development issue receptorMTORserine/threonine protein kinase mTOr Poly (aDP-ribose) polymeraseTemsirolimus (Torisel) Everolimus (Afinitor) Olaparib (aZD2281)PARPPDGFRPlatelet-derived growth issue receptor alphaimatinib mesylate (gleevac) sorafenib (nexavar) sunitinib (sutent) Pazopanib (Votrient) nilotinib (Tasigna) axitinib (inlyta) Dasatinib (sprycel) Bortezomib (Velcade) Carfilzomib (Kyprolis)PSMC2 PSMC5 PSMC26s protease regulatory subunit 7 26s protease regulatory subunit 8 26s protease regulatory subunit 10BNote: ainformation from Termglinchan et al and DrugBank Version 4.5. republished with permission of Dovepress, from Onco Targets Ther, candidate cancer-targeting agents identified by expression-profiling arrays, Termglinchan V, Wanichnopparat W, Suwanwongse K, et al, 6, copyright 2013; permission conveyed via Copyright Clearance center, inc.77 Wishart Ds, Knox c, guo ac, et al. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006;34(Database problem):D668 672, by permission of Oxford University Press.78 Abbreviations: FDa, Food and Drug administration; her2, human epidermal growth element receptor two; nsclc, non-small-cell lung cancer; egFr, epidermal growth aspect receptor; all, acute lymphoid leukemia; gisT, gastrointestinal stromal tumor; cMl, chronic myeloid leukemia; rcc, renal cell carcinoma; alK, anaplastic lymphoma kinase.OncoTargets and Therapy 2017:submit your manuscript | www.dovepress.comDovepresschaiyawat et alDovepressTable 6 Up-regulated proteins and genes which might be targets of FDa-approved non-antineoplastic drugsGene ATP1A1 ATP1B1 DHODH Protein name na+/K+-aTPase Dihydroorotate dehydrogenase (quinone), mitochondrial FDA-approved drug Digoxin Digitoxin Leflunomide Drug category antiarrhythmia agent immunosuppressive agent Disease indicationa For the remedy and management of congestive cardiac insufficiency, arrhythmias, and heart failure. For the management on the indicators and symptoms of active ra. has also been utilized for the prevention of acute and chronic rejection in recipients of solid organ trasnplants and is designated by the FDa as an orphan drug for PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19927011 this use. For the prophylaxis of organ rejection in sufferers getting allogeneic renal, cardiac, or hepatic transplants.

East cancer, pancreatic cancer Monotherapy in patients with deleterious

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