Product Name :
ASP2535
Description:
ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer’s disease.
CAS:
374886-51-8
Molecular Weight:
382.42
Formula:
C22H18N6O
Chemical Name:
4-[3-(6-phenylpyridin-3-yl)-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
Smiles :
CC(C)C1=NN=C(C2C=NC(=CC=2)C2C=CC=CC=2)N1C1=CC=CC2=NON=C21
InChiKey:
FQGLDGKVKDPVLO-UHFFFAOYSA-N
InChi :
InChI=1S/C22H18N6O/c1-14(2)21-24-25-22(28(21)19-10-6-9-18-20(19)27-29-26-18)16-11-12-17(23-13-16)15-7-4-3-5-8-15/h3-14H,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Epoprostenol Epigenetics
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer’s disease.|Product information|CAS Number: 374886-51-8|Molecular Weight: 382.Natalizumab Cytoskeleton 42|Formula: C22H18N6O|Chemical Name: 4-[3-(6-phenylpyridin-3-yl)-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole|Smiles: CC(C)C1=NN=C(C2C=NC(=CC=2)C2C=CC=CC=2)N1C1=CC=CC2=NON=C21|InChiKey: FQGLDGKVKDPVLO-UHFFFAOYSA-N|InChi: InChI=1S/C22H18N6O/c1-14(2)21-24-25-22(28(21)19-10-6-9-18-20(19)27-29-26-18)16-11-12-17(23-13-16)15-7-4-3-5-8-15/h3-14H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:35120786 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ASP2535 potently inhibits rat GlyT1 (IC50=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro.|In Vivo:|ASP2535 (0.3-3 mg/kg; p.o) attenuates working memory deficit in MK-801-treated mice and visual learning deficit in neonatally phencyclidine (PCP)-treated mice. ASP2535 (1-3 mg/kg, p.o.) also improves the PCP-induced deficit in prepulse inhibition in rats.|Products are for research use only. Not for human use.|
