Rger dose group. Total 25(OH)D concentration was significantly different across groups (p < 0.001). Circulating 25(OH)D3 decreased in the placebo and vitamin D2 group (p < 0.001), but increased in the vitamin D3 group (p < 0.001). Y Total 25(OH)D concentration was significantly higher in vitamin D supplemented groups than placebo and in D3 group than D2. Circulating 25(OH)D reached the plateau at 3 months. Larger proportion of women receiving 100,000 IU/month reached 25(OH)D concentrations >75 nmol/L at 6 months than those receiving 50,000 IU/months.Healthy women (n = 18)Lehmann et al. (2013) [89]Healthy adults (n = 107)YLogan et al. (2013) [88]Healthy men and women (n = 61)YMazahery, Stonehouse, von Hurst (2015) [15]Healthy ElbasvirMedChemExpress Elbasvir premenopausal women (n = 61)YNutrients 2015, 7 Table 2. Cont.Vadadustat site Relationship withType of Vitamin DDosing RegimenStudyPopulation CharacteristicsStudy Design/Duration/GroupsSeasonDescriptionNelson et al. (2009) [41]Healthy premenopausal women (n = 112)Randomised double blind placebo trial/21 weeks/daily placebo or daily 800 IU DYYHigher increase in vitamin D supplemented group than placebo. Starting the trial in winter was associated with a greater response. The magnitude of summer increase in 25(OH)D concentration was a significant predictor of the change. Larger proportion of subjects achieved 25(OH)D concentrations of 75 nmol/L or more; 3.7 , 37.0 , 63.8 and 90.4 in the placebo, 1000, 2000 and 4000 IU groups, respectively. D3 tended to increase 25(OH)D concentration more than D2 (p = 0.08).Ng et al. (2014) [47]Healthy adults (n = 292)Randomised double blind placebo control trial/3 months/daily placebo or daily 1000, 2000 or 4000 IU D Un-blinded randomised control trial/3 months/daily 400 IU D2 or D3 + daily 675 mg calcium in al grups Double-blind, randomised clinical trial/11 weeks/daily 200 or 1000 IU D3 Prospective randomised intervention/60 days/Single dose of 300,000 IU D2 or D3 administered orally or intramuscularly Open-labelled, randomised, parallel group trial/3 months/daily 2000 IU D2 or monthly 60,000 IU DYNimitphong et al. (2013) [55] Putman et al. (2013) [56] Romagnoli et al. (2008) [85]Healthy adults (n = 39) Healthy adolescents with vitamin D sufficiency (n = 53) Women residence of nursing homes with vitamin D deficiency (n = 32) Healthy nulliparous and lactating women (n = 178)YNYSeason of enrolment was a significant predictor. Rapid and consistent increase with oral D3, but slow and gradual increase with both vitamins given intramuscularly. Based on the AUC, D3 was twice as potent as D. All women together, daily regimen was more effective than monthly regimen.YYSaadi et al. (2007) [38]YNutrients 2015, 7 Table 2. Cont.Relationship withType of Vitamin DStudyStudy Design/Duration/GroupsSeasonPopulation CharacteristicsDosing RegimenDescriptionTalwar et al. (2007) [14]Healthy postmenopausal women (n = 208)Randomised placebo control trial/36 months /daily placebo or daily 800 IU D3 for the first 2 years and then daily 2000 IU D3 for the third year in the vitamin D group + daily 1200?500 mg calcium in both groups Randomised double blind trial/14 days/daily 4000 IU D2 or 4000 IU D3 Randomised intervention trial/2? months/daily 1000 or 4000 IU D3 Randomised double blind placebo control trial/one year/monthly placebo or monthly 30,000 or 60,000 IU D3 Open labelled randomised clinical trial/6 months/Single intramuscular 300,000 IU D3 or 6 divided oral doses (weekly 50,000 IU D3 for 4 weeks then monthly 50,000 I.Rger dose group. Total 25(OH)D concentration was significantly different across groups (p < 0.001). Circulating 25(OH)D3 decreased in the placebo and vitamin D2 group (p < 0.001), but increased in the vitamin D3 group (p < 0.001). Y Total 25(OH)D concentration was significantly higher in vitamin D supplemented groups than placebo and in D3 group than D2. Circulating 25(OH)D reached the plateau at 3 months. Larger proportion of women receiving 100,000 IU/month reached 25(OH)D concentrations >75 nmol/L at 6 months than those receiving 50,000 IU/months.Healthy women (n = 18)Lehmann et al. (2013) [89]Healthy adults (n = 107)YLogan et al. (2013) [88]Healthy men and women (n = 61)YMazahery, Stonehouse, von Hurst (2015) [15]Healthy premenopausal women (n = 61)YNutrients 2015, 7 Table 2. Cont.Relationship withType of Vitamin DDosing RegimenStudyPopulation CharacteristicsStudy Design/Duration/GroupsSeasonDescriptionNelson et al. (2009) [41]Healthy premenopausal women (n = 112)Randomised double blind placebo trial/21 weeks/daily placebo or daily 800 IU DYYHigher increase in vitamin D supplemented group than placebo. Starting the trial in winter was associated with a greater response. The magnitude of summer increase in 25(OH)D concentration was a significant predictor of the change. Larger proportion of subjects achieved 25(OH)D concentrations of 75 nmol/L or more; 3.7 , 37.0 , 63.8 and 90.4 in the placebo, 1000, 2000 and 4000 IU groups, respectively. D3 tended to increase 25(OH)D concentration more than D2 (p = 0.08).Ng et al. (2014) [47]Healthy adults (n = 292)Randomised double blind placebo control trial/3 months/daily placebo or daily 1000, 2000 or 4000 IU D Un-blinded randomised control trial/3 months/daily 400 IU D2 or D3 + daily 675 mg calcium in al grups Double-blind, randomised clinical trial/11 weeks/daily 200 or 1000 IU D3 Prospective randomised intervention/60 days/Single dose of 300,000 IU D2 or D3 administered orally or intramuscularly Open-labelled, randomised, parallel group trial/3 months/daily 2000 IU D2 or monthly 60,000 IU DYNimitphong et al. (2013) [55] Putman et al. (2013) [56] Romagnoli et al. (2008) [85]Healthy adults (n = 39) Healthy adolescents with vitamin D sufficiency (n = 53) Women residence of nursing homes with vitamin D deficiency (n = 32) Healthy nulliparous and lactating women (n = 178)YNYSeason of enrolment was a significant predictor. Rapid and consistent increase with oral D3, but slow and gradual increase with both vitamins given intramuscularly. Based on the AUC, D3 was twice as potent as D. All women together, daily regimen was more effective than monthly regimen.YYSaadi et al. (2007) [38]YNutrients 2015, 7 Table 2. Cont.Relationship withType of Vitamin DStudyStudy Design/Duration/GroupsSeasonPopulation CharacteristicsDosing RegimenDescriptionTalwar et al. (2007) [14]Healthy postmenopausal women (n = 208)Randomised placebo control trial/36 months /daily placebo or daily 800 IU D3 for the first 2 years and then daily 2000 IU D3 for the third year in the vitamin D group + daily 1200?500 mg calcium in both groups Randomised double blind trial/14 days/daily 4000 IU D2 or 4000 IU D3 Randomised intervention trial/2? months/daily 1000 or 4000 IU D3 Randomised double blind placebo control trial/one year/monthly placebo or monthly 30,000 or 60,000 IU D3 Open labelled randomised clinical trial/6 months/Single intramuscular 300,000 IU D3 or 6 divided oral doses (weekly 50,000 IU D3 for 4 weeks then monthly 50,000 I.
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