Egree value of 89 and aInt. J. Mol. Sci. 2018, 19,6 ofThe Calcium-ATPase Inhibitors medchemexpress network reports a scalefree topology, indicating that very connected proteins are located within the central region, as indicated in Figure 3B. Immediately after analyzing the degree of connectivity by quantity of Figure 3. (A) Interaction network of T. cruzi strain CL Breiner. The nodes (proteins) are presented in nodes, we discovered that this distribution had a linear CD47 Inhibitors medchemexpress tendency behavior using a adverse slope, using a R2 black plus the score related with all the interaction is presented in colors, blue getting additional trusted of 0.735 (unpublished figure). Even though this really is not a higher worth in comparison with other networks (likely than orange. (B) Interaction network of T. cruzi strain CL Breiner. The axes (interactions) are due to lack of coverage), and onsufficient condition toconnected)with posterior topological calculations. it is actually a a scale of orange (much less proceed to blue (additional connected) the nodes represented in black We also observedthelarge numbersizenodescircle indicates its degree connectivity (Figure 3B). (proteins) of a network. The of with the using a higher degree of of connectivity (degree). 2.5. Identification of Proteins Potentially Involved within the AKTLike Pathway from the Parasite 2.5. Identification of Proteins Potentially Involved within the AKTLike Pathway in the Parasite Immediately after acquiring a listlist human proteins associated towards the PI3KAKTmTOR pathway, we mapped Following getting a of of human proteins connected towards the PI3KAKTmTOR pathway, we them with them with proteinsthe protein rotein protein rotein interaction network of TcAKTlike mapped proteins included in integrated inside the interaction network of T. cruzi, like T. cruzi, (Figure 4A).TcAKTlike (Figure 4A). The comprehensive final results are reported inTopological properties have been such as The total benefits are reported in Supplementary Table S3. Supplementary Table S3. calculated, exactly where the TcAKTlike yielded where the TcAKTlike yielded a degree worth of 89 and a Topological properties have been calculated, a degree value of 89 plus a betweenness centrality of 0.002, which can be connected of a pleiotropic nature.linked proteins had been also analyzed othervisualized betweenness centrality to 0.002, which can be The other to a pleiotropic nature. The and proteins as bluealso analyzed and visualized as blue nodes respective4B. The proteins with their respective have been nodes in Figure 4B. The proteins with their in Figure calculations of degrees of connectivity (degree) and betweenness connectivity (degree) and Table S4. calculations of degrees of centrality are reported in betweenness centrality are reported in Table S4.Figure (A) Protein rotein interaction network with the AKTlike protein signaled in yellow, exactly where Figure 4.4. (A) Protein rotein interaction network with the AKTlike protein signaled in yellow, where the axes that connect with all the closest neighboring nodes (positioned in the center of network) are the axes that connect using the closest neighboring nodes (positioned within the center from the the network) are highlighted in red. (B) Protein rotein interaction network with proteins represented as nodes, highlighted in red. (B) Protein rotein interaction network with proteins represented as white white nodes, and in blue are were that have been mapped together with the PI3KAKTmTOR human of human and in blue are those that those mapped using the PI3KAKTmTOR pathway ofpathwayproteins. proteins.Many of the proteins reported connectivity information inside the imply and are also rela.