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www.nature.com/scientificreportsOPENEffect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell linesBritta Stapel1, Catharina Melzer2, Juliane von der Ohe2, Peter Hillemanns2, Stefan Bleich1, Kai G. Kahl1 Ralf HassBreast cancer would be the most prevalent malignancy amongst women worldwide whilst GLUT4 Species ovarian cancer represents the leading reason for death among gynecological malignancies. Girls affected by these cancers displayed heightened rates of important depressive disorder, and antidepressant treatment with selective serotonin reuptake inhibitors (SSRIs) is regularly recommended. Lately, narrative reviews and meta-analyses showed elevated recurrence risks and mortality prices in SSRI-treated ladies with breast and ovarian cancer. We hence examined whether or not 3 frequently prescribed SSRIs, fluoxetine, sertraline and citalopram, have an effect on proliferation or glucose uptake of human breast and ovarian cancer cell lines characterized by unique malignancies and metastatic potential. SSRI therapy or serotonin stimulation with therapeutically relevant concentrations more than a variety of time periods revealed no constant dose- or time-dependent effect on proliferation rates. A marginal, but considerable enhance in glucose uptake was observed in SK-OV-3 ovarian cancer cells upon fluoxetine or sertraline, but not citalopram therapy. In 3 breast cancer cell lines and in two more ovarian cancer cell lines no significant impact of SSRIs on glucose uptake was observed. Our data recommend that the observed boost in recurrence- and mortality prices in SSRI-treated cancer individuals is unlikely to be linked to antidepressant therapies. Significant depression disorder (MDD) represents certainly one of the preceding mood issues worldwide with a 12-months prevalence of approximately 10 within the United States1. The Globe Well being Organization predicted depression to become the leading cause of illness burden by 2030; it outcomes in st.