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Biological approach, molecular function, and molecular pathway, was utilized to categorize
Biological method, molecular function, and molecular pathway, was made use of to categorize the proteins into families and subfamilies with shared functions. Statistical evaluation. All the outcomes are presented because the means 6 SD. The statistical significance was determined by 1-way analysis of variance followed by post hoc test (Dr. SPSS II, Chicago, IL). Differences have been viewed as important when p , 0.05. 1. Maitra, A. et al. Genomic alterations in cultured human embryonic stem cells. Nat. Genet. 37, 1099103 (2005). two. Baker, D. E. et al. Adaptation to culture of human embryonic stem cells and oncogenesis in vivo. Nat. Biotechnol. 25, 20715 (2007). three. Sareen, D. et al. Chromosome 7 and 19 trisomy in cultured human neural progenitor cells. PLoS A single 4, e7630 (2009). 4. Ivanovic, Z. Hypoxia or in situ normoxia: The stem cell paradigm. J. Cell. Physiol. 219, 27175 (2009). 5. Ames, B. N., Shigenaga, M. K. Hagen, T. M. Oxidants, antioxidants, and the degenerative illnesses of aging. Proc. Natl. Acad. Sci. U. S. A. 90, 7915922 (1993). six. van Gent, D. C., Hoeijmakers, J. H. Kanaar, R. Chromosomal stability along with the DNA double-stranded break connection. Nat. Rev. Genet. 2, 19606 (2001). 7. Wang, F., Thirumangalathu, S. Loeken, M. R. Establishment of new mouse embryonic stem cell lines is enhanced by physiological glucose and oxygen. Cloning Stem Cells 8, 10816 (2006). 8. Fehrer, C. et al. Lowered oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan. Aging Cell 6, 74557 (2007). 9. Li, T. S. Marban, E. Physiological levels of reactive oxygen species are needed to sustain genomic stability in stem cells. Stem Cells 28, 1178185 (2010). ten. Li, T. S. et al. Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair. Cardiovasc. Res. 89, 15765 (2011). 11. Noon, A. T. Goodarzi, A. A. 53BP1-mediated DNA LPAR3 drug double strand break repair: insert poor pun right here. DNA Repair (Amst) ten, 1071076 (2011). 12. Kitagawa, R. Kastan, M. B. The ATM-dependent DNA damage signaling pathway. Cold Spring Harb. Symp. Quant. Biol. 70, 9909 (2005). 13. Kinoshita, T. et al. Ataxia-telangiectasia mutated (ATM) deficiency JAK review decreases reprogramming efficiency and results in genomic instability in iPS cells. Biochem. Biophys. Res. Commun. 407, 32126 (2011). 14. Foreman, J. et al. Reactive oxygen species made by NADPH oxidase regulate plant cell growth. Nature 422, 44226 (2003). 15. Niethammer, P., Grabher, C., Appear, A. T. Mitchison, T. J. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature 459, 99699 (2009). 16. Owusu-Ansah, E. Banerjee, U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature 461, 53741 (2009). 17. Costa, J. L., Meijer, G., Ylstra, B. Caldas, C. Array comparative genomic hybridization copy quantity profiling: a brand new tool for translational study in strong malignancies. Semin. Radiat. Oncol. 18, 9804 (2008). 18. Robinton, D. A. Daley, G. Q. The promise of induced pluripotent stem cells in research and therapy. Nature 481, 29505 (2012). 19. White, M. P., Rufaihah, A. J., Liu, L., Ghebremariam, Y. T., Ivey, K. N., Cooke, J. P. Srivastava, D. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem Cells 31, 9203 (2013). 20. Takahashi, K. et al. Induction of pluripote.

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