Heir interaction. If there was a significant F-test, imply separation was completed by the PROC MIXED PDIFF statement. Inside a subset of cats that had a serum SDMA 14 g/dL at baseline or through the 6-month feeding trial, a single measure t-test was performed to evaluate the effect of time on meals. Data are reported as least square means (LSM) SEM. Statistical significance was declared at P 0.05.ResultsA total of 80 cats completed the 6 month study. Eighteen of 51 cats (35.three ) consuming test food, and 7 of 54 cats (13.0 ) consuming owner’s-choice foods had incomplete data or failed to finish the study. On the 80 cats completing the study, imply age was 11.5 years (variety, 9 to 18 years). There had been 31 males and 49 females, with imply SD initial physique weight of five.four 1.five kg (variety 2.eight.five kg) (Table two). Concentrations of blood hemoglobin, and serum sodium and renal function biomarkers in cats at baseline, 3 months, and 6 months are shown in Table three (least square means SEM). Cats consuming test food showed considerable decreases in serum Cr and BUN concentrations across time. Cats consuming owner’s-choice foods showed significant increases in serum SDMA concentrations at three and six months compared with baseline (all P 0.05). For serumTable 2. Cats finishing the 6 month feeding trial had been classified in line with age, sex, initial physique weight, and irrespective of whether they have been fed test food or owner’s-choice foods. Food Test Food Owner’s-Choice Foods N 33 47 Age, years Mean (variety) 11.7 (98) 11.three (97) Sex 20 SF; 13 NM 29 SF, 18 NM Initial Physique Weight, kg Mean SD (variety) five.five 1.five (three.three.five) 5.3 1.five (2.eight.1)doi:10.1371/journal.pone.0153654.tPLOS One particular | DOI:10.1371/journal.CA125 Protein manufacturer pone.0153654 April 14,6 /Impact of Diet regime on SDMA and Cr in Geriatric CatsSDMA (P = 0.03), Cr (P = 0.02), and BUN (P = 0.001), there have been considerable interactions among diet plan and time on study. Hemoglobin concentrations remained steady across time for cats consuming both test food and owner’s-choice foods. Serum sodium concentrations decreased across time in cats consuming owner’s-choice foods at three and 6 months compared with baseline (P 0.05), but had been steady in cats consuming test meals.ACTB Protein web For serum sodium (P = 0.02), there was a significant interaction involving diet plan and time on study. Urine specific gravity in cats consuming owner’s-choice foods also showed important decreases at three and 6 months compared with baseline (all P 0.PMID:23672196 05). There was no change in either group of cats for urine protein:Cr ratio across time.Table three. Hemoglobin, serum sodium and renal function biomarkers, and urinalysis parameters of cats at baseline (initial) and immediately after consuming test food or owner’s-choice foods for three and 6 months (mean SEM). Owner’s- Option Foods Variety of Animals, N Hemoglobin: Hemoglobin (g/dL) Initial 3 months 6 months Serum electrolytes: Serum Sodium (mmol/L) Initial 3 months 6 months Renal function markers: Urea Nitrogen (mg/dL) Initial 3 months 6 months Serum Creatinine (mg/dL) Initial 3 months six months Serum SDMA (g/dL) Initial 3 months six months Urinalysis parameters: Urine Distinct Gravity Initial 3 months six months Urine Protein:Cr Ratio Initial 3 months 6 monthsTest FoodTwo-way ANOVA Evaluation (P values) Main Impact Diet plan Primary Effect Time Impact of Eating plan x Time0.88 13.44 0.21 13.32 0.25 13.53 0.34 13.17 0.26 13.41 0.30 13.88 0.42 0.42 152.three 0.31a 151.1 0.27b 150.9 0.29b 151.9 0.38 151.four 0.32 151.9 0.35 0.21 27.96 0.86 28.15 0.89 27.99 0.81 1.45 0.04 1.44 0.04 1.42 0.04 ten.32 0.43a 11.19 0.53b 11.39 0.53b 28.
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