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Product Name :
TMC647055

Description:
TMC647055 is a potent and selective non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase with EC50 value of 82 nM . Hepatitis C virus (HCV) NS5B polymerase is a RNA-dependant RNA-polymerase that is responsible for viral replication and plays an important role in HCV life cycle. HCV is a major cause of chronic liver disease and acute hepatitis, ultimately leading to liver failure, cirrhosis and hepatocellular carcinoma . TMC647055 is a selective and cell-permeating HCV NS5B inhibitor. In RNA polymerase primer-dependent transcription assay, TMC647055 inhibited HCV NS5B polymerase with IC50 value of 34 nM. In the Huh7-Luc cell line, TMC647055 inhibited the replication of genotype 1b replicon with EC50 values of 77 and 139 nM measured with luciferase readout and qRT-PCR readout, respectively. TMC647055 exhibited high-affinity interaction with NS5B across all genotypes (except for genotype 2b) with median KD value < 35 nM. In Huh7-Luc replicon cells, TMC647055 (750 nM) reduced 30 cell colonies formation. Also, TMC647055 (1.5 μM and 3.75 μM) reduced HCV replicon RNA .

CAS:
1204416-97-6

Molecular Weight:
606.73

Formula:
C32H38N4O6S

Chemical Name:
28-cyclohexyl-7-hydroxy-22-methoxy-10,16-dimethyl-13-oxa-9λ⁶-thia-1,8,10,16-tetraazapentacyclo[16.8.1.1²,⁶.1³,²⁶.0²⁰,²⁵]nonacosa-2(29),3,5,7,18,20(25),21,23,26(28)-nonaene-9,9,17-trione

Smiles :
COC1=CC2C=C3CN4C(=C(C5CCCCC5)C5=CC=C(C=C45)C(O)=NS(=O)(=O)N(C)CCOCCN(C)C3=O)C=2C=C1 |t:27|

InChiKey:
UOBYJVFBFSLCTQ-UHFFFAOYSA-N

InChi :
InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
TMC647055 is a potent and selective non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase with EC50 value of 82 nM . Hepatitis C virus (HCV) NS5B polymerase is a RNA-dependant RNA-polymerase that is responsible for viral replication and plays an important role in HCV life cycle. HCV is a major cause of chronic liver disease and acute hepatitis, ultimately leading to liver failure, cirrhosis and hepatocellular carcinoma . TMC647055 is a selective and cell-permeating HCV NS5B inhibitor. In RNA polymerase primer-dependent transcription assay, TMC647055 inhibited HCV NS5B polymerase with IC50 value of 34 nM. In the Huh7-Luc cell line, TMC647055 inhibited the replication of genotype 1b replicon with EC50 values of 77 and 139 nM measured with luciferase readout and qRT-PCR readout, respectively. TMC647055 exhibited high-affinity interaction with NS5B across all genotypes (except for genotype 2b) with median KD value Product information|CAS Number: 1204416-97-6|Molecular Weight: 606.73|Formula: C32H38N4O6S|Chemical Name: 28-cyclohexyl-7-hydroxy-22-methoxy-10,16-dimethyl-13-oxa-9λ⁶-thia-1,8,10,16-tetraazapentacyclo[16.{{Zoliflodacin} MedChemExpress|{Zoliflodacin} Antibiotic|{Zoliflodacin} Biological Activity|{Zoliflodacin} Data Sheet|{Zoliflodacin} manufacturer|{Zoliflodacin} Cancer} 8.{{Asiatic acid} medchemexpress|{Asiatic acid} Apoptosis|{Asiatic acid} Protocol|{Asiatic acid} In stock|{Asiatic acid} manufacturer|{Asiatic acid} Epigenetic Reader Domain} 1.PMID:24278086 1²,⁶.1³,²⁶.0²⁰,²⁵]nonacosa-2(29),3,5,7,18,20(25),21,23,26(28)-nonaene-9,9,17-trione|Smiles: COC1=CC2C=C3CN4C(=C(C5CCCCC5)C5=CC=C(C=C45)C(O)=NS(=O)(=O)N(C)CCOCCN(C)C3=O)C=2C=C1 |t:27||InChiKey: UOBYJVFBFSLCTQ-UHFFFAOYSA-N|InChi: InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Author: bet-bromodomain.