Intubate, use NIV or discharge the patient had not been decided. Exclusion criteria: immediate intubation, NIV, or discharge from Cat 1. Baseline demographics and vital signs were collected before the initiation of your trial (Figure 1). The CO2SMO Plus! using the ETCO2/flow sensor was used for obtaining bedside measurements. Sufferers would breathe by means of the ETCO2/flow sensor for 60 seconds with nose clips. Results The threshold value for RSBI that discriminated most effective in between PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/2073874 no NIV and also the need to have for NIV was determined in 61 patients. Thirty-five sufferers who did not require ventilatory support had a mean RSBI of 105, and 26 individuals with NIV had a imply RSBI of 222 (P = 0.0001). A receiver-operating-characteristic curve was constructed primarily based upon the dataset in increments of 10 for the RSBI (Figure two). An RSBI > 120 yielded a sensitivity of 0.81 and also a specificity of 0.74 for determining the need for NIV. A likelihood ratio positive (LR+) of three.14 further illustrates the formidable predictive worth on the 120 RSBI.Figure 1 (abstract P169)Figure 2 (abstract P169)Conclusion A RSBI of 120 or higher, as reflected by f/VT ratio, may be a predictor of when NIV assistance need to be considered. Further prospective randomized research are needed to validate the worth of 120.P170 Is threshold beneficial in accelerating weaning from mechanical ventilation?S Vieira1, R Condessa1, J Brauner1, A Saul1, A Silva1, M Silva1, L Borges2, M Moura1, M Alves1, F Kutchak1, L Biz1, C Dieterich1 1Hospital de Cl icas de Porto Alegre, Brazil; 2Hospital Moinhos de Vento, Porto Alegre, Brazil Critical Care 2007, 11(Suppl 2):P170 (doi: ten.1186/cc5330) Introduction Threshold can be utilised as a physiotherapic tool in order to boost muscle strength, and this impact could be valuable in weaning patients. However, you’ll find still controversies thinking about its advantages throughout weaning from mechanical ventilation (MV). The aim of this study is always to evaluate its effects in such a circumstance. Solutions Patients below MV for a lot more than 48 hours and prone to weaning had been studied. They were randomized for the manage group or towards the threshold group and followed daily until extubation, tracheostomy or death. The threshold group was educated twice each day. All cardiorespiratory variables, maximal inspiratory (PImax) and expiratory (PEmax) pressures had been registered twice every day during the observation period. The length of weaning and success or Procyanidin B2 failure were registered. Variables were compared by evaluation of variance, Mann hitney U test and the chi-square test. Results are shown because the median, mean and standard deviation or as percentages. The significance level was P < 0.05. Results Sixty patients were studied (52 men, mean age 64 ?17 years, 18 with chronic obstructive pulmonary disease in threshold group vs 15 in control group). Comparing initial versus final cardiorespiratory variables in both groups, no important differences were observed with exception of PImax (increased from ?3.5 ?14.4 to ?0.2 ?13.4 cmH2O in threshold group and changed from ?7.1 ?9.8 to ?4.4 ?9.6 cmH2O in control group, P < 0.05) and PEmax (increased from 24.7 ?12.7 to 29.4 ?12.1 cmH2O in threshold group and changed from 30.9 ?13.5 to 27.1 ?9.4 cmH2O in control group, P < 0.05). No reduction was observed in the length of weaning (1.87 days with threshold versus 1.98 days in control group, P > 0.05). There was no difference concerning weaning achievement (73.5 with threshold versus 61.five in control group, P > 0.05). Conclusions.