Product Name: K-14585
Description: K-14585 is a proteinase-activated receptor 2 antagonist. Pretreatment with K-14585 inhibited PAR(2)-mediated p65 NFkappaB phosphorylation and NFkappaB-DNA binding. K-14585 inhibited SLIGKV-stimulated IL-8 production, but given alone increased IL-8. K-1
CAS NO: 1581270-11-2 Product: RIP2 kinase inhibitor 2
Synonym: K-14585; K 14585; K14585.
IUPAC Chemical Name: (S)-6-amino-N-((S)-1-(benzhydrylamino)-1-oxo-3-phenylpropan-2-yl)-2-(2-(3-(1-(2,6-dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indol-5-yl)ureido)acetamido)hexanamide
In ChiKey: Pyruvate Dehydrogenase inhibitors
SMILE Code: ClC1=CC=CC(Cl)=C1CN2C(C=C3)=C(C(CN4CCCC4)=C2)C=C3NC(NCC(N[[email protected]](C(N[[email protected]@H](CC5=CC=CC=C5)C(NC(C6=CC=CC=C6)C7=CC=CC=C7)=O)=O)CCCCN)=O)=O
Appearance: Solid powder
Purity: 98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Medchemexpress
Storage Condition: Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: 2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 – 4 C for short term (days to weeks), or -20 C for long term (months).PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22129061
Chemical Formulaļ¼šC51H56Cl2N8O4
ExactMass: 914.3802
Molecular Weight: 915.961
Elemental Analysis: C, 66.88; H, 6.16; Cl, 7.74; N, 12.23; O, 6.99